People
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Sankar GHOSH, PH.D.
Chairman and Silverstein and Hutt Family Professor of Microbiology & Immunology
sg2715@cumc.columbia.edu
Dr. Ghosh received his Ph.D. in Molecular Biology from the Albert Einstein College of Medicine in 1988. He carried out his postdoctoral research as an Irvington Institute postdoctoral fellow with Dr. David Baltimore at the Whitehead Institute of MIT in Cambridge, MA. It was there that Dr. Ghosh began his seminal work in understanding the regulation of Nuclear Factor-kappa B (NF-kappa B / NF-kB), a transcription factor that plays a critical role in regulating the expression of a large number of genes involved in the mammalian immune system. Dr. Ghosh’s research led to the first cloning of NF-kB and IkB proteins, and their characterization, including the demonstration of the role of IkB phosphorylation in the activation of NF-kB.
Dr. Ghosh began his independent research career at Yale University School of Medicine in 1991, where he was a Professor in the Departments of Immunobiology and Molecular Biophysics & Biochemistry, and an Investigator of the Howard Hughes Medical Institute. At Yale his laboratory made numerous original findings that helped establish the mechanism of transcriptional regulation of NF-kB proteins, identification and characterization of signaling intermediates in innate and adaptive immune system, and identification and characterization of a subset of Toll-like receptors. In 2008 he was recruited to Columbia University to be the chairman of the Department of Microbiology and Immunology.
A biochemist, immunologist and microbiologist, Dr. Ghosh continues to be best known for his work on NF-kB. Because NF-kB plays an important role in regulating the expression of a number of genes involved in inflammation and the immune responses, his research has implications for the treatment of arthritis, colitis, dermatitis, asthma, and other inflammatory diseases, as well as diseases such as cancer and muscular dystrophy. However his research interests have expanded over the years and encompasses the study of long non-coding RNAs and microRNAs in the inflammatory process. His recent work has also illuminated novel mechanisms and pathways by which the NF-kB pathway influences immune responses to cancer.
Suneeta Krishnareddy
Assistant Professor of Medicine
sk3222@cumc.columbia.edu
I am a gastroenterologist at Columbia University, and have been working in the lab since 2014. I am studying the role of toll like receptors on commensalism and disease susceptibility. We are trying to determine the role of the innate immune system in determining commensal colonization and how this then leads to differences in susceptibility to infectious and inflammatory GI conditions.
My favorite thing to do in the city is go for bike rides with my family along the west side highway, and end up either at Dinosaur Barbecue or Ample Hills Creamery.
Jingyao Zhao
Post-Doctoral Research Scientist
jz3095@cumc.columbia.edu
I recently joined the Ghosh lab after completing my PhD at the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science. In my previous lab, I mainly focused on hematopoietic stem cells and T cells. In the Ghosh lab, my main interest is about the immunotherapy to cancer. I hope to improve cancer therapy through this research.
When I am out of lab, I like running, cooking Chinese food, and hiking.
Felipe Leao
POST-DOCTORAL RESEARCH SCIENTIST
fbl2113@cumc.columbia.edu
I am currently a postdoctoral research scientist at the Ghosh Lab. I am currently studying the transcriptional regulation of a recently described TLR-inducible gene, trying to identify some of the genomic regions and molecular mechanisms responsible for its induced expression in macrophages. My favorite thing to do in NYC is going to bars that have a good selection of beers, food, and great live music. Lots of options, so I think it is impossible to get bored here.
Vincent Guichard
POST-DOCTORAL RESEARCH SCIENTIST
vag2141@cumc.columbia.edu
After completing my Ph.D. in Paris, where I worked on naïve T cell and the pathways essential for their differentiation, I joined the Ghosh lab as postdoctoral research scientist. Here, I study the activation of innate lymphoid cells. I am currently focused on the NF-kB pathway in the ILC2s. In New York City I enjoy walking in the park with my dog, hanging out with my friends and finding new bars or restaurants to try.
Christine Ghobrial
POST-DOCTORAL RESEARCH SCIENTIST
cg3249@cumc.columbia.edu
I am postdoctoral research scientist with an interest in studying cancer immunology. My current project centers around identifying molecules that target the NF-kB pathway for the purpose of cancer immunotherapy. Within the city, I enjoy spending time with friends and family. I also enjoy exploring to discover what’s in my “backyard”.
Alyssa Shearer
PhD Candidate
ams2481@cumc.columbia.edu
I am a graduate student in the Nutritional and Metabolic Biology department at CUMC, with interests in genetics, nutritional biochemistry, and the immune system. I am currently studying how long non-coding RNAs regulate gene expression and inflammation within the intestinal immune system. This project will help to elucidate genetic susceptibility to inflammatory bowel diseases, such as Celiac Disease, whose genetic underpinnings are largely unknown.
My favorite things to do in NYC are going on runs in Central Park, eating lots of good vegetarian food, and visiting the many art museums.
Ruxiao Tian
PhD Candidate
rt2750@cumc.columbia.edu
I am a graduate student in the Department of Microbiology & Immunology at Columbia University. I am interested in genetics, molecular biology, and immunology. I am currently studying how certain long non-coding RNAs regulate inflammation and how the dysfunctional regulation of these lncRNAs contribute to autoimmune diseases like celiac disease and systemic lupus erythematosus. Outside of the lab, I play the cello. My favorite things to do in NYC are going to new restaurants, taking pictures of NYC, and going on long walks at riverside park.
Crystal Bussey
Lab Manager
cb2720@cumc.columbia.edu
I have been a member of the Ghosh lab for many years and have had the opportunity to work with many wonderful students, postdocs and faculty over that time. As I often interface with various research labs, collaborators, administrative offices, regulatory agencies and vendors, I see first-hand the intricacies of life in a research community. It’s exciting to know that in some way you may contribute to the next great discovery.
My favorite things to do in New York are visiting Times Square like I’ve never seen it before, eating my way from the west side to the east side, and watching the beautiful sunsets over the Hudson.
Andry Dominguez
Executive Assistant
Department of Microbiology and Immunology
ad3270@cumc.columbia.edu
I am the Assistant to the Chairman of Microbiology and Immunology who is also the head of the Ghosh Lab.
Ghosh Lab alumni
Postdoctoral Fellows
Thomas Postler
Principal Scientist, International AIDS Vaccine Initiative, Inc.
Haihong Zhong
Senior Scientist, MedImmune, Gaithersburg, MA
Roderick J. Phillips
Li Lin
Craig Fenwick
Director of the Immunology and Allergy Immune Monitoring Platform, Lausanne University Hospital, Switzerland
Michael J. May
Associate Professor, Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA
Reinhard Voll
Professor and Medical Director, Department of Rheumatology and Clinical Immunology, University of Freiburg, Germany
Eijiro Jimi
Professor, Kyushu University, Japan
Guolong Zhang
Associate Professor of Molecular Immunology, College of Agricultural Science and Natural Resources, Oklahoma State University, OK
Dekai Zhang
Associate Professor, Center for Infectious and Inflammatory Diseases, Texas A&M University, Houston, TX
Ki-young Lee
Professor, Sungkyunkwan University, Seoul, Korea
Fulvio D’ Acquisto
Professor and Managing Director, Health Sciences Research Center, University of Roehampton, London, UK
Ralf Marienfeld
Researcher, Institute for Pathology, University of Ulm, Germany
Dola Sengupta
Senior Grants Administrator, Columbia University Medical Center
Ian Strickland
Principal Scientist, Janssen, Flanders, Belgium
Jan Schulze-Luehrmann
Jie Dong
Associate Service Fellow, CDC/NIOSH, Morgantown, WV
Brian Poligone
Director, Skin Lymphoma Group, Rochester Skin Lymphoma Center
Meixiao Long
Assistant Professor, College of Medicine, Ohio State University
Ping Rao
Assistant Professor, Department of Pathology, Duke University School of Medicine, Durham, NC
Sung-gyoo Park
Professor, Gwanju Institute of Science & Technology, Korea
Ramkumar Mathur
Assistant Professor, Department of Geriatrics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND
Sanchita Bhatnagar
Assistant Professor, Department of Biochemistry, University of Virginia, Charlottesville, VA
Teruki Dainichi
Assistant Professor, Department of Dermatology, Kyoto University School of Medicine, Japan
Andrea Oeckinghaus
Assistant Professor, Institute of Molecular Tumor Biology, University of Munster, Germany
Dev M Bhatt
Senior Associate Scientist, Amgen, San Francisco
Ainara Castellanos Rubio
Assistant Professor, Department of Genetics, Physical Anthropology and Animal Physiology, BioCruces Research Institute, University of the Basque Country - UPV/EHU, Spain
Matthew Hayden
Assistant Professor, Department of Dermatology, Geisel School of Medicine, Dartmouth University
Alice Lepelley
Junior Researcher, Imagine Institute of Genetic Diseases, Paris, France
Hyunju Oh
Research Scientist, Technical University, Munich, Germany
Yenkel Grinberg Bleyer
Assistant Professor, INSERM: Lyon, France
Flavia Carneiro
Research Scientist, Instituto Carlos Chagas-FIOCRUZ-PR, Brazil
Aisling O’Hara
Senior Scientist at The Janssen Pharmaceutical Company, Springhouse, PA
Lauren Vaughn
Postdoctoral Scientist, University of South Carolina, SC
Graduate Students
Elizabeth Kopp
Research Scientist, Department of Immunobiology, Yale University, New Haven, CT
Lucy Budde
Family Physician, Boulder, CO
Helena Mancebo (née SuYang)
CEO, Multispan Inc. San Francisco, CA
Chun Wu
Partner and Managing Director, Boston Consulting Group, Hong Kong/China Group
Changchun Xiao
Associate Professor, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA
Jae-Hyuck Shim
Associate Professor, Department of Medicine, University of Massachusetts Medical School, Worcester, MA
Shannon Bailey
Associate Director, WuXi NextCODE, Jamaica Plain, MA
Elizabeth C. Ziegler
Phillip West
Assistant Professor, Department of Microbial Pathogenesis and Immunology, Texas A&M University
Matthew Hayden
Assistant Professor, Department of Dermatology, Geisel School of Medicine, Dartmouth University, NH
Alicia Koblansky
Investigator-Molecular Immunology at ViiV Healthcare, Chapel Hill, NC
John Seeley
Director of Research Operations at Columbia University College of Physicians and Surgeons, New York, NY
Sujatha Gurunathan
Science Writer, New York, NY
Arnab De
Senior Scientist, Merck, NJ
Hirotsugu Hatai (visiting from University of Tokyo)
Medical Science Liaison, Abbvie, Tokyo
Naama Kanarek (visiting from Hebrew University, Israel)
Postdoctoral Fellow, Whitehead Institute, Cambridge, MA
Tan Zhang
